Ubiquitin conjugating enzymes 7,8 and 9
AssigneeHuman Genome Sciences, Inc.
InventorsJian Ni, Reiner Gentz, Mark D. Adams
Life of this patent
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Abstract
Human UCE 7, UCE 8 and UCE 9 polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods of utilizing such polypeptide for the treatment of the proliferation of malignant cells. Antagonists against such polypeptides and their uses as a therapeutic to treat Alzheimer's disease, atrophying skeletal muscle, African swine fever virus and apoptotic cell death are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in UCE 7, 8 and 9 nucleic acid sequences and the concentration of polypeptides encoded by such sequences.
Claims15
An isolated polypeptide comprising a mature polypeptide having an amino acid sequence encoded by a polynucleotide which is at least a 95% identical to a member selected from the group consisting of:
- (a) a polynucleotide encoding a polypeptide comprising amino acids 2 to 154 of SEQ ID NO:4;
- and
- (b) a polynucleotide encoding a polypeptide comprising amino acids 2 to 193 of SEQ ID NO:6.
An isolated polypeptide comprising a mature polypeptide having an amino acid sequence encoded by a polynucleotide having at least a 95% identity to a member selected from the group consisting of:
- (a) a polynucleotide encoding the same mature polypeptide encoded by the human cDNA in ATCC Deposit No. 75876;
- and
- (b) a polynucleotide encoding the same mature polypeptide encoded by the human cDNA in ATCC Deposit No. 75878.
Dependencies are inferred from the claim text.