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AssigneeDiatide, Inc.
InventorsRichard T. Dean, Daniel A. Pearson, John Lister-James, Edgar R. Civitello
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This invention relates to radiotherapeutic reagents and peptides, radiodiagnostic reagents and peptides, and methods for producing labeled radiodiagnostic and radiotherapeutic agents. Specifically, the invention relates to VIP receptor binding peptides, derivatives and analogues of VIP, and embodiments of such peptides radiolabeled with a radioisotope, as well as methods and kits for making, radiolabeling and using such peptides for radiodiagnostic and radiotherapeutic purposes. The invention specifically relates to VIP receptor binding peptide derivatives and analogues of VIP radiolabeled with technetium-99m and uses thereof as scintigraphic imaging agents. The invention also specifically relates to VIP receptor binding peptide derivatives and analogues of VIP radiolabeled with cytotoxic radioisotopes such as rhenium-186 (.sup.186 Re) and rhenium-188 (.sup.188 Re) for use as radiotherapeutic agents. Methods and kits for making, radiolabeling and using such peptides diagnostically and therapeutically in a mammalian body are also provided.
A reagent for preparing a radiopharmaceutical, comprising a synthetic, receptor-binding vasoactive intestinal peptide (VIP) covalently linked to a technetium or rhenium chelating moiety, wherein said chelating moiety is incorporated into the reagent during synthesis of the peptide, and wherein the radiopharmaceutical when labeled with technetium or rhenium has a VIP receptor binding affinity that is not less than about one-tenth the affinity of radioiodinated native VIP for said receptor.
A composition of matter selected from the group consisting of:
A vasoactive intestinal peptide (VIP) reagent for preparing a radiopharmaceutical, comprising
Dependencies are inferred from the claim text.