Technetium-99M labeled peptides for thrombus imaging
AssigneeDiatide, Inc.
InventorsRichard T. Dean, John Lister-James
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Abstract
This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to specific binding peptides, methods and kits for making such peptides, and methods for using such peptides labeled with technetium-99m via a radiolabel-binding moiety covalently linked to the peptide to image thrombus sites in a mammalian body.
Claims12
A reagent for preparing a thrombus imaging agent for imaging a thrombus within a mammalian body comprising a specific binding peptide and a technetium-99m binding moiety covalently linked to the specific binding peptide, wherein the peptide binds to a component of a thrombus, the technetium-99m binding moiety having formula:
- C(pgp).sup.s -(aa)-C(pgp).sup.s
- wherein C(pgp).sup.s is a cysteine having a protected thiol group and (aa) is an amino acid.
Dependencies are inferred from the claim text.