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US 5,849,240 AGranted
Method of preparing sustained release pharmaceutical compositions
AssigneeEuro-Celtique S.A.
InventorsRonald Brown Miller, Stewart Thomas Leslie, Sandra Therese Antoinette Malkowska, Derek Allan Prater, Treavor John Knott, Joanne Heafield, Deborah Challis
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Abstract
A process for the manufacture of particles comprises mechanically working a mixture of a drug and a hydrophobic and/or hydrophilic fusible carrier in a high speed mixture so as to form agglomerates, breaking the agglomerates to give controlled release particles and optionally continuing the mechanical working with the optional addition of a low percentage of the carrier or diluent.
Claims21
A process for the manufacture of controlled release particles, which comprises:
- (a) mechanically working in a high-speed mixer, a mixture of a particulate drug and a particulate, hydrophobic and/or hydrophilic fusible carrier or diluent having a melting point of 35.degree. to 150.degree. C. and optionally a release control component comprising water-soluble fusible material or a particulate, soluble or insoluble organic or inorganic material, at a speed and energy input and at a drug to fusible carrier(s) ratio and by a process which allows the carrier or diluent to melt or soften to form agglomerates of irregular shape;
- (b) breaking down the irregular shaped agglomerates to give controlled release particles;
- and optionally
- (c) continuing mechanically working optionally with the addition of a low percentage of the carrier or diluent;
- and optionally
- (d) repeating steps (c) and possibly (b) one or more times.
3 more elements
Dependencies are inferred from the claim text.