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US 5,849,189 AGranted
Hollow fiber blood purifying membrane and process for its production
AssigneeTeijin Limited
InventorsShingo Emi, Kouji Soga, Satoshi Fukuhara
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AssigneeTeijin Limited
InventorsShingo Emi, Kouji Soga, Satoshi Fukuhara
Estimating the term…
A hollow fiber blood purifying membrane which is a hollow fiber membrane substantially composed of cellulose acetate, has a substantially non-oriented distribution of cellulose acetate polymer particles on the inner surface of the hollow fibers, has a dense layer with a thickness in the range of 30-1000 nm on both the inner and outer surface of the hollow fibers and a porous structure which is substantially uniform at the membrane wall between the two dense layers, and has an in vitro ultrafiltration rate (UFR) of 10 to 50 ml/m.sup.2 .multidot.mmHg.multidot.hr and a (in vivo UFR)/(in vitro UFR) ratio of at least 0.3, a blood plasma albumin permeation blockage of at least 90%, and an in vivo .beta..sub.2 -microglobulin (.beta..sub.2 -MG) sieving coefficient of at least 0.4, as well as a process for its production.
A hollow fiber blood purifying membrane having an inner and outer surface comprising cellulose acetate, and having a substantially non-oriented distribution of cellulose acetate polymer particles on the inner surface of the hollow fibers, said fibers comprising a dense layer with a thickness in the range of 30 to 1000 nm on both the inner and outer surface portions of said hollow fibers and a porous structure which is substantially uniform between the two dense layers, and having an in vitro ultrafiltration rate (UFR) of 10 to 50 ml/m.sup.2 .multidot.mmHg.multidot.hr and an (in vivo UFR)/(in vitro UFR) ratio of at least 0.3, a blood plasma albumin permeation blockage of at least 90%, and an in vivo .beta..sub.2 -microglobulin (.beta..sub.2 -MG) sieving coefficient of at least 0.4.
Dependencies are inferred from the claim text.