Transgenic mouse deficient in T-cells
AssigneeJeongsun SEO
InventorsJeong-Sun Seo, Soonhee Kim, Woong-Yang Park
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Abstract
The present invention relates to a transgenic mouse deficient in T-cells, which is provided by fusing human heat shock protein (Hsp) gene with H2K promoter and transferring it to a mouse. Transgenic mouse line with a shrunken thymus and edficient in T-cells not having mature T-cells can be obtained.
Claims5
A transgenic mouse lacking functional T-cells, wherein the germ cells and somatic cells of said mouse comprise recombinant DNA consisting of a 2.0 kb HindIII-EcoRI fragment of a human H2K gene promoter operably linked to a 2.3 kb BamHI-HindIII fragment of human heat shock protein 70 gene, and wherein expression of said human heat shock protein 70 in said mouse results in said mouse exhibiting a shrunken thymus and lacking functional T-cells.
Dependencies are inferred from the claim text.