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US 5,847,212 AGranted
Process for the preparation of iohexol
AssigneeAbbott Laboratories
InventorsXiu Chun Wang, Ashok V. Bhatia, Steven A. Chamberlin
Life of this patent
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Abstract
Provided is a novel process for the preparation of iohexol having reduced number of isolated intermediates and significantly reduces or eliminates the use of ion-exchange resins required to desalinate the final product.
Claims16
A process for making iohexol comprising the steps of:
- a. combining 5-acetamino-N,N'-bis-(2,3-dihydroxy-propyl)-2,4,6-triiodo-1,3-benzene-dica rboxamide, a solvent, glycidol, and a base to form a reaction mixture;
- b. maintaining the reaction mixture for a period of time sufficient to allow the reaction to proceed to completion;
- and
- c. isolating iohexol.
1 more element
A process for making iohexol comprising the steps of:
- a. heating a first reaction mixture of 5-acetamino-N,N'-bis-(2,3-dihydroxy-propyl)-2,4,6-triiodo-1,3-benzene-dica rboxamide in the presence of DMSO and triethylamine under conditions to achieve dissolution;
- b. adding glycidol to the first reaction mixture to form a second reaction mixture;
- c. maintaining the second reaction mixture for a period of time sufficient to allow the reaction to proceed to completion;
- d. crystallizing iohexol from the second reaction mixture in the presence of isopropanol.
1 more element
A process for making iohexol comprising the steps of:
- a. Combining 5-acetamino-N,N'-bis-(2,3-dihydroxy-propyl)-2,4,6-triiodo-1,3-benzene-dica rboxamide, a solvent, glycidol, and a tertiary amine to form a reaction mixture;
- b. maintaining the reaction mixture for a period of time sufficient to allow the reaction to proceed to completion;
- and
- c. isolating iohexol.
1 more element
Dependencies are inferred from the claim text.