Amphiphilic fluorine derivatives with telomeric structures; preparation procedure and biomedical applications

A fluorinated compound having the formula:

• ##STR24## in which R.sub.F is a C.sub.2 -C.sub.18 fluorinated radical;
• X is an C.sub.1 -C.sub.24 alkylene or fluoroalkylene group, linear or branched, having at least one subsitituent independently selected from the group consisting of --CON(R')--, --SO.sub.2 N(R')--, --S--, --O-- or --N(R')-- wherein R' is H or a C.sub.1 to C.sub.6 alkyl or fluoroalkyl radical;
• and when X is branched, a part of X can be R.sub.F ;
• R.sup.1 is H or CH.sub.3 ;
• R.sup.2 is selected from the group consisting of the radicals (CH.sub.2).sub.p --C(CH.sub.2 OH).sub.3, wherein p=0 to 3;
• Z--R.sub.4, wherein Z is a monovalent or bivalent radical selected from the group consisting of --NH--, --(CH.sub.2).sub.r --N-- (R.sup.1)--, --(CH.sub.2).sub.r --O--, or (CH.sub.2).sub.r --S--, wherein r=2 to 4, and R.sup.1 is as defined above;
• and
• R.sup.4 is a monovalent radical derived from an ose, an oside or an amine derivative thereof;
• R.sup.3 is a amino acid residue obtained by removal of a hydrogen atom from the NH.sub.2 group thereof;
• n=1 to 50, provided that R.sup.2 is (CH.sub.2).sub.p --C(CH.sub.2 OH).sub.3 when n=1;
• and
• m=0 or 1 to 200, provided that 0.2.ltoreq.n/n+m.ltoreq.1.