US 5,847,192 AGranted

Boronic compound complexing reagents and complexes

AssigneesProlinx, Inc., Systemix, Inc.

InventorsMark L. Stolowitz, Robert J. Kaiser, Kevin P. Lund, Steven M. Torkelson

Life of this patent

Estimating the term…

Abstract

Boron compound complexing reagents and methods of synthesizing these reagents are disclosed. These reagents, including those shown as General Formula I and General Formula II may be used, after further reactions described herein, to complex with boronic compounds, such as phenylboronic acid or derivatives thereof. ##STR1##

Claims4

Dependent claims

A reagent of General Formula I:

##STR29## wherein group Z comprises a spacer selected from a saturated or unsaturated chain up to about 6 carbon equivalents in length, an unbranched saturated or unsaturated chain of from about 6 to 18 carbon equivalents in length with at least one of intermediate amide or disulfide moieties, and a polyethylene glycol chain of from about 3 to 12 carbon equivalents in length;
wherein group R.sub.1 is a electrophilic or nucleophilic moiety selected from the group consisting of acrylamide, amino, bromo, dithiopyridyl, bromoacetamide, hydrazide, N-hydroxysuccinimide ester, N-hydroxysulfosuccinimide ester, imidate ester, imidazolide, iodo, iodoacetamide, maleimide, and thiol moieties;
and
wherein group R.sub.2 is one of an alkyl group and a methylene group with an electronegative moiety.

1 more element

Dependencies are inferred from the claim text.

Facts

Application: 08/689,341Filed 5 Aug 1996 · continuation in part
Priority: 28 Jan 1994
Granted: 8 Dec 1998
Term ends: Not estimatedThe source records don’t support an estimate.

Classification20 codes

C07D 207/452
With only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide: with…
C07C 229/38
Compounds containing amino and carboxyl groups bound to the same carbon skeleton: having amino groups bound to acyclic carbon atoms and carboxyl…
C07C 233/49
With the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom: having the carbon atom of…
C07C 233/51
With the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom: having the carbon atom of…

Family

Serial188,531Parent of this continuation-in-part · filed 28 Jan 1994
US 5,594,151 AParent of this continuation-in-part
US 5,847,192 AThis patent

From the US filing history. Foreign family members aren’t listed.

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Abstract

Facts

Application

08/689,341Filed 5 Aug 1996 · continuation in part

Priority

28 Jan 1994

Granted

8 Dec 1998

Term ends

Not estimatedThe source records don’t support an estimate.

Classification20 codes

C07D 207/452
With only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide: with…
C07C 229/38
Compounds containing amino and carboxyl groups bound to the same carbon skeleton: having amino groups bound to acyclic carbon atoms and carboxyl…
C07C 233/49
With the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom: having the carbon atom of…
C07C 233/51
With the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom: having the carbon atom of…