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US 5,847,186 AGranted
Process for preparing asymmetric compound by using metal complex
AssigneeNagase & Co., Ltd.
InventorsMasakatsu Shibasaki, Hiroaki Sasai, Takayoshi Arai
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AssigneeNagase & Co., Ltd.
InventorsMasakatsu Shibasaki, Hiroaki Sasai, Takayoshi Arai
Estimating the term…
A process for producing an asymmetric compound using a metal complex containing no rare earth metal element is disclosed. The process affords an optically active compound having high optical purity. Optically active binaphthol having the chemical formula ##STR1## and lithium aluminum hydride are reacted, or the optically active binaphthol, a dialkyl aluminum hydride, and a base containing an alkali metal (or a base containing alkaline earth metal) are reacted to prepare a metal complex comprising optically active binaphthol, aluminum, and alkali metal (or alkaline earth metal). This metal complex can be used as a catalyst to perform an asymmetric Michael reaction, an asymmetric phosphonylation reaction, or the like, to obtain, in a high yield, an asymmetric compound having high optical purity.
A process for producing an asymmetric Michael addition compound comprising a step of performing an asymmetric Michael reaction using a metal complex, wherein said metal complex is a reaction product of (a) an optically active binaphthol or a derivative thereof, and (b) an alkali metal aluminum hydride or alkali metal aluminum hydride compound.
A process for producing an asymmetric hydrophosphonylated compound comprising the step of performing an asymmetric hydrophosphonylation reaction using a metal complex, wherein said metal complex is a reaction product of (a) an optically active binaphthol or a derivative thereof, and (b) an alkali metal aluminum hydride or alkali metal aluminum hydride compound.
A process for producing an asymmetric Michael addition compound comprising the step of performing an asymmetric Michael reaction using a metal complex, wherein said metal complex is a reaction product of (a) an optically active binaphthol or a derivative thereof, (b) a dialkylaluminum hydride, and (c) a base containing an alkali metal or an alkaline earth metal.
A process for producing an asymmetric hydrophosphonylated compound comprising the step of performing an asymmetric hydrophosphonylation reaction using a metal complex, wherein said metal complex is a reaction product of (a) an optically active binaphthol or a derivative thereof, (b) a dialkylaluminum hydride, and (c) a base containing an alkali metal or an alkaline earth metal.
Dependencies are inferred from the claim text.