21-nor-vitamin D compounds
AssigneeWisconsin Alumni Research Foundation
InventorsHector F. DeLuca, Jerzy Wicha
Life of this patent
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Abstract
21-norvitamin D.sub.3 analogs in which the methyl group normally attached to the side chain at carbon 20 has been replaced by a hydrogen atom. The compounds are characterized by a marked intestinal calcium transport activity while exhibiting much lower activity than 1.alpha.,25-dihydroxyvitamin D.sub.3 in their ability to mobilize calcium from bone. Because of their preferential calemic activity, these compounds would be useful for the treatment of diseases where bone formation is desired, such as osteodystrophy. Novel intermediates formed during the synthesis of the end products are also disclosed.
Claims1
A compound having the formula:
- ##STR7## where X.sub.3 is hydrogen or a hydroxy-protecting group, and Z is selected from the group consisting of Y, --OY,!--CH.sub.2 OY, --C.dbd.--CY and --CY.dbd.CHY, where the double bond may have the cis or trans stereochemical configuration, and where Y is a radical of the structure:
- ##STR8## where m and n independently represent integers from 0 to 5, where R.sup.1 is selected from the group consisting of hydrogen, hydroxy, protected-hydroxy, fluoro, trifluoromethyl, and C.sub.1-5 alkyl, which may be straight-chain or branched and optionally bear a hydroxy or protected-hydroxy substituent;
- R.sup.2 is selected from the group consisting of hydrogen, fluoro, trifluoromethyl, and C.sub.1-5 alkyl, which may be straight-chain or branched and optionally bear a hydroxy or protected-hydroxy substituent, or R.sup.1 and R.sup.2, taken together, represent an oxo group, or an alkylidene group, .dbd.CR.sup.6 R.sup.7, or the group --CH.sub.2)p--, where p is an integer from 2 to 5;
- where each of R.sup.3 and R.sup.4 is independently selected from the group consisting of hydrogen, fluoro, trifluoromethyl, and C.sub.1-5 alkyl, which may be straight-chain or branched and optionally bear a hydroxy or protected-hydroxy substituent, or R.sup.3 and R.sup.4, taken together, represent an oxo group or the group --CH.sub.2)q--, where q is an integer from 2 to 5;
- where R.sup.1 represents hydrogen, hydroxy, protected-hydroxy or C.sub.1-5 alkyl;
- and where each of R.sup.6 and R.sup.7 is independently selected from the group consisting of hydrogen, fluoro, trifluoromethyl, and C.sub.1-5 alkyl, which may be straight-chain or branched and optionally bear a hydroxy or protected-hydroxy substituent;
- with the proviso that (a) when Z is Y, Y is not methyl or a radical of the structure --(CH.sub.2).sub.3 C(CH.sub.3).sub.2 OH:
- (b) when R.sup.5 is --OH and R.sup.1 and R.sup.2 are both --H and m plus n is equal to 2, then either R.sup.3 or R.sup.4 cannot be --CH.sub.3 ;
- (c) when R.sup.1, R.sub.2, R.sup.3 and R.sup.4 are all --H, and m plus n is equal to 4, then R.sup.5 cannot be --CH.sub.3 ;
- or (d) when R.sup.2, R.sup.3 and R.sup.4 are all --CH.sub.3 and R.sup.5 is --OH and m and n are each equal to 1, then R.sup.1 cannot be --OH.
Dependencies are inferred from the claim text.