Certain aminosterol compounds and pharmaceutical compositions including these compounds
AssigneeMagainin Pharmaceuticals Inc.
InventorsMichael Zasloff, Ann Shinnar, William Kinney, Steven Jones
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Abstract
Aminosterol compounds are described that are useful as inhibitors of the sodium/proton exchanger (NHE). Methods of using such aminosterols compounds are also enclosed, including those employing compounds that are inhibitors of a spectrum of NHEs as well as those using compounds that are inhibitors of only one specific NHE. Advantageous screening techniques and assays for evaluating a compound's therapeutic activity are also disclosed.
Claims10
A compound having the following formula:
- ##STR121## or a pharmaceutically acceptable salt thereof.
A compound having the following formula:
- ##STR122## or a pharmaceutically acceptable salt thereof.
A compound having the following formula:
- ##STR123## or a pharmaceutically acceptable salt thereof.
A compound having the following formula:
- ##STR124## or a pharmaceutically acceptable salt thereof.
A compound having the following formula:
- ##STR125## or a pharmaceutically acceptable salt thereof.
A compound having the following formula:
- ##STR126## or a pharmaceutically acceptable salt thereof.
A compound having the following formula:
- ##STR127## or a pharmaceutically acceptable salt thereof.
A compound having the following formula:
- ##STR128## or a pharmaceutically acceptable salt thereof.
A compound having the following formula:
- ##STR129## or a pharmaceutically acceptable salt thereof.
A compound having the following formula:
- ##STR130## or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.