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US 5,847,165 AGranted
Suksdorfin analogs, compositions thereof, and methods for making and using thereof
AssigneeThe University of North Carolina at Chapel Hill
InventorsKuo-Hsiung Lee, Mark Cosentino, Lan Xie, Mark Manak
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Abstract
Disclosed are compounds of Formula I: ##STR1## wherein R.sup.1 through R.sup.6 are defined herein. Also disclosed are pharmaceutical compositions and methods of using these compositions for treating retroviral infections. Finally, a stereoselective method for synthesizing compounds of Formula I is described.
Claims8
A method for synthesis of 3',4'-di-O-acyl-cis-khellactone derivatives comprising:
- oxidizing an optionally substituted seselin in the presence of a chiral ligand selected from the group consisting of DHQD-CLB, DHQD-PHN, (DHQD).sub.2 -PYR, DHQ-PHN, DHQ-CLB, DHO-MEQ and (DHQ).sub.2 -PYR to yield racemic cis-dihydroxy-khellactone;
- and
- esterifying said racemic cis-dihydroxykhellactone with an acyl chloride to form a 3',4'-di-O-acyl-cis-khellactone derivative.
Dependencies are inferred from the claim text.