Water soluble derivatives of cannabinoids
AssigneeVirginia Commonwealth University
InventorsBilly R. Martin, Raj K. Razdan
Life of this patent
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Abstract
Water-soluble esters of tetrahydrocannabinoids, which are well-suited for administration in therapeutic aqueous formulations, having following general formula: ##STR1## wherein a - - - b designates a 9(10) or a 9(8) double bond, R' is a --(CH.sub.2).sub.n -- linkage group where n is 1-8, and R is a -(CZ.sub.2).sub.n - linkage group where n is 6 or more and Z independently is H or a substituent such as a lower alkyl group, and the pharmaceutically acceptable salts of these compounds.
Claims9
A compound of the formula ##STR8## wherein a - - - b designates a 9(10) or a 9(8) double bond, R' is a --(CH.sub.2).sub.n -- linkage group where n is 1-8, and R is a -(CZ.sub.2).sub.n - linkage group where n is 6 or more and Z independently is H or a lower alkyl group, and pharmaceutically acceptable salts thereof.
3-(5'-cyano-1',1'-dimethylheptyl)-1-(4-N-morpholinobutyryloxy)-.DELTA..s up.8 -tetrahyrocannabinol, and pharmaceutically acceptable salts thereof.
A pharmaceutical composition comprising a compound solubilized in an aqueous medium, wherein said compound is of the formula ##STR9## wherein a - - - b designates a 9(10) or a 9(8) double bond, R' is a --(CH.sub.2).sub.n -- linkage group where n is 1-8, and R is a -(CZ.sub.2).sub.n - linkage group where n is 6 or more and Z independently is H or a lower alkyl group, and pharmaceutically acceptable salts thereof.
A method of relieving pain in a mammal comprising administering to said mammal an effective analgesic amount of a pharmaceutical composition containing a compound solubilized in an aqueous medium, wherein said compound is of the formula ##STR10## wherein a - - - b designates a 9(10) or a 9(8) double bond, R' is a --(CH.sub.2).sub.n -- linkage group where n is 1-8, and R is a -(CZ.sub.2).sub.n - linkage group where n is 6 or more and Z independently is H or a lower alkyl group, and pharmaceutically acceptable salts thereof.
A method of treating asthma, nausea, or the AIDS wasting syndrome in a human comprising administering to said human an effective therapeutic amount of a pharmaceutical composition containing a compound solubilized in an aqueous medium, wherein said compound is of the formula ##STR11## wherein a - - - b designates a 9(10) or a 9(8) double bond, R' is a --(CH.sub.2).sub.n -- linkage group where n is 1-8, and R is a -(CZ.sub.2).sub.n - linkage group where n is 6 or more and Z independently is H or a lower alkyl group, and pharmaceutically acceptable salts thereof .
Dependencies are inferred from the claim text.