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US 5,847,118 AGranted
Methods for the manufacture of amorphous cefuroxime axetil
AssigneeApotex Inc.
InventorsKhashayar Karimian, Mehrnoush Motamedi, Salvatore Zinghini
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Abstract
A process for preparing pure amorphous cefuroxime axetil comprising the steps of dissolving crystalline cefuroxime axetil in a highly polar organic solvent and adding the resulting solution to water, or alternatively, dissolving crystalline cefuroxime axetil in a highly polar solvent and adding small quantities of water to the organic solution and adding the resulting organic-aqueous solution to water.
Claims6
A process of preparing an amorphous cefuroxime axetil which comprises the steps of:
- (a) dissolving crystalline cefuroxime axetil in a volume of a highly polar organic solvent only sufficient to dissolve it, and adding the resulting solution to water;
- or
- (b) dissolving crystalline cefuroxime axetil in a volume of a highly polar organic solvent only sufficient to dissolve it, adding water to the resulting solution and subsequently adding the resulting aqueous-organic solution to water;
- wherein the highly polar organic solvent is selected from the group consisting of a sulfoxide, an amide and formic acid.
1 more element
Dependencies are inferred from the claim text.