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US 5,847,110 AGranted
Method of reducing a schiff base
AssigneeBiomedical Frontiers, Inc.
InventorsPaul R. Dragsten, Gregory J. Hansen
Life of this patent
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Abstract
The invention relates to methods of reducing Schiff bases and making chelator conjugates by treating with borane-pyridine complex.
Claims47
A method of reducing a Schiff base, the method comprising the step of:
- reducing the Schiff base with borane-pyridine complex in an aqueous solvent with pH at least about 4.
A method for making a covalently bonded conjugate of an amine and a water soluble carrier, the method comprising the steps of:
- reacting a water soluble carrier with an amine;
- and
- reducing the reacted water soluble carrier with borane-pyridine complex at a pH at least about 4.
Dependencies are inferred from the claim text.