Method of preparing mixed glucosamine salts
AssigneeRotta Research B.V. Amsterdam (Swiss Branch)
InventorsMaura De Wan, Giuseppe Volpi
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Abstract
A method of preparing a therapeutically active crystalline form of glucosamine sulphate which is stable at ambient temperature and humidity and corresponds to the empirical formula: ##STR1## in which M represents a metal selected from the group consisting of Na, K, Ca, Mg, x=1 if y=2, and x=2 if y=1, wherein glucosamine hydrochloride and a sulphate of a metal selected from Na, K, Ca, Mg are reacted in the stoichiometric ratio defined by formula (I), in an aqueous solvent, and the stable crystalline form is precipitated by the addition of a liquid precipitating agent miscible with water.
Claims5
A method of preparing a therapeutically active crystalline form of glucosamine sulphate which is stable at ambient temperature and humidity and corresponds to the empirical formula:
- ##STR5## in which M represents a metal selected from the group consisting of Na, K, Ca, and Mg,
- x=1 if y=2, and
- x=2 if y=1,
- wherein glucosamine hydrochloride and a sulphate of a metal selected from the group consisting of Na, K, Ca, and Mg are used as the starting materials, the method comprising directly reacting said glucosamine hydrochloride and said sulphate in the stoichiometric ratio defined by formula (I), in an aqueous solvent, and precipitating said stable crystalline form of glucosamine sulphate by addition of a liquid precipitating agent miscible with water.
Dependencies are inferred from the claim text.