TNF receptor death domain ligand proteins
AssigneeGenetics Institute, Inc.
InventorsLih-Ling Lin, Jennifer Chen
Life of this patent
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Abstract
Novel TNF receptor death domain ("TNF-R1-DD") ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.
Claims15
An isolated polynucleotide selected from the group consisting of:
- (a) a polynucleotide comprising a fragment of the nucleotide sequence of SEQ ID NO:3, wherein said fragment encodes a protein having TNF-R1-DD ligand protein activity;
- and
- (b) a polynucleotide encoding a TNF-R1-DD ligand protein comprising a fragment of the amino acid sequence of SEQ ID NO:4, wherein said fragment has TNF-R1-DD ligand protein activity.
An isolated polynucleotide encoding a protein having TNF-R1-DD ligand protein activity, said polynucleotide comprising the nucleotide sequence of SEQ ID NO:3 from nucleotide 2 to nucleotide 415.
An isolated polynucleotide encoding a protein having TNF-R1-DD ligand protein activity, said protein comprising the amino acid sequence of SEQ ID NO:4.
Dependencies are inferred from the claim text.