DNA encoding interleukin IL-1.beta. mutant
AssigneeOtsuka Pharmaceutcal Co., Ltd.
InventorsSatoru Nakai, Mayumi Kaneta, Yoshikazu Kikumoto, Yeong-Man Hong, Kazuyoshi Kawai, Setsuko Takegata, Kiyoshi Ishii, Yasuo Yanagihara, Yoshikatsu Hirai
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Abstract
A homogeneous interleukin 1.beta. (IL-1.beta.), its derivative having a modified amino acid sequence of IL-1.beta., a gene coding for said derivative, medical composition comprising said derivative as a pharmaceutically effective component and a medicinal use of homogeneous IL-1.beta. and the derivative.
Claims5
An isolated or purified DNA molecule encoding an interleukin-1.beta. mutant, wherein said mutant contains a mutation in the amino acid sequences of interleukin-1.beta. represented by Formula (A), and wherein said mutation is selected from the group consisting of (a), (b), and (c) as defined below,
- ______________________________________ Formula (A) ______________________________________ ##STR7## ##STR8## ##STR9## ##STR10## ##STR11## ##STR12## ##STR13## ##STR14## ##STR15## ##STR16## ##STR17## ##STR18## ##STR19## ##STR20## ##STR21## ValSerSer ______________________________________ (a) Cys at the 8position is replaced by Ala;
- (b) Cys at the 71position is replaced by Ser or Ala;
- and (c) Cys at the 71position is replaced by Ser or Ala, and Cys at the 8position is replaced by Ala.
An isolated or purified DNA molecule having a nucleotide sequence encoding (Ser.sup.71)IL-1.beta..
An isolated or purified DNA molecule having a nucleotide sequence encoding (Ala.sup.8, Ala.sup.71) -IL-1.beta..
Dependencies are inferred from the claim text.