DNA constructs encoding CD4 fusion proteins
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsManfred Schubert, George G. Harmison, II, Chang-Jie Chen, Akhil Banjerjea
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Abstract
The subject invention relates to defective, interfering HIV particles and uses thereof. In particular, these particles encode a membrane bound receptor protein, as well as multitarget ribozymes, which together interfere with the production of infectious HIV by a host cell by downregulating the amount of HIV envelope protein on the surface of the cell as well as the amount of HIV genomic RNA.
Claims22
A DNA construct which encodes a chimeric protein, said DNA construct comprising a chimeric gene operably linked to at least one human immunodeficiency virus LTR promoter sequence, where said chimeric gene comprises a first sequence encoding the ectodomain portion of the CD4 protein and a second sequence encoding the transmembrane and cytoplasmic portions of an envelope protein.
A DNA construct which encodes a complete CD4 protein;
- said construct comprising at least one HIV LTR promoter sequence operably linked to a nucleic acid sequence encoding said CD4 protein.
A DNA construct selected from the group consisting of DIRz27, MONORz37, MONORz6, MONARz63-6, PENTARz51 and PENTARz63.
The DNA construct HDPACK1 having the sequence shown in SEQ ID NO:9.
The DNA construct HD1 (T7) having the sequence shown in SEQ ID NO:3.
Dependencies are inferred from the claim text.