Erythromycin A 9-0 oxime derivatives endowed with antibiotic activity
AssigneeZambon Group S.p.A.
InventorsFranco Pellacini, Giovanna Schioppacassi, Enrico Albini, Daniela Botta, Stefano Romagnano, Francesco Santangelo
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Abstract
Erythromycin 9-oxime derivatives wherein a phenyl or heterocylic group is attached indirectly to the 9-position of erythromycin A through an alkylene diamine bridging member. These compounds exhibit broad spectrum antibiotic activity.
Claims7
A compound of formula ##STR18## wherein A is a phenyl group or a heterocycle with 5 or 6 members containing 1 or more heteroatoms selected from the group consisting of nitrogen, oxygen and sulphur, optionally substituted with from 1 to 3 groups, the same or different, selected from the group consisting of straight or branched C.sub.1 -C.sub.4 alkyl or alkoxy groups, C.sub.1 -C.sub.2 alkylenedioxy groups, C.sub.1 -C.sub.4 alkylsulphonyl groups, phenyl, phenoxy, hydroxy, carboxy, nitro, halogen and trifluoromethyl groups;
- R.sub.1 and R.sub.2, the same or different, represent a hydrogen atom or straight or branched C.sub.1 -C.sub.4 alkyl group;
- n is 1 or 2;
- m is an integer comprised between 1 and 8;
- r is an integer comprised between 2 and 6;
- M represents a group of the formula:
- ##STR19## that carries the oximinyl moiety at the 9 position;
- wherein R.sub.3 is a hydrogen atom or a methyl group;
- and its pharmaceutically acceptable salts.
Dependencies are inferred from the claim text.