Antibodies specific for platelet-activating factor acetylhydrolase
AssigneeICOS Corporation
InventorsLawrence S. Cousens, Christine D. Eberhardt, Patrick Gray, Hai Le Trong, Larry W. Tjoelker, Cheryl L. Wilder
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Abstract
The present invention provides purified and isolated polynucleotide sequences encoding human plasma platelet-activating factor acetylhydrolase. Also provided are materials and methods for the recombinant production of platelet-activating factor acetylhydrolase products which are expected to be useful in regulating pathological inflammatory events.
Claims15
An antibody which specifically binds to human platelet-activating factor acetylhydrolase (PAF-AH) comprising the PAF-AH amino acid sequence set out in SEQ ID NO:8.
The monoclonal antibody produced by hybridoma 90G11D (ATCC HB 11724).
The monoclonal antibody produced by hybridoma 90F2D (ATCC HB 11725).
The monoclonal antibody produced by hybridoma 143A (ATCC HB 11900).
The hybridoma cell line 90G11D (ATCC HB 11724).
The hybridoma cell line 90F2D (ATCC HB 11725).
The hybridoma cell line 143A (ATCC HB 11900).
A humanized antibody which specifically binds to human PAF-AH comprising the PAF-AH amino acid sequence set out in SEQ ID NO:8.
A monoclonal antibody which specifically binds to murine PAF-AH comprising the PAF-AH amino acid sequence set out in SEQ ID NO:31.
A monoclonal antibody which specifically binds to canine PAF-AH comprising the PAF-AH amino acid sequence set out in SEQ ID NO:32.
A monoclonal antibody which specifically binds to bovine PAF-AH comprising the PAF-AH amino acid sequence set out in SEQ ID NO:33.
A monoclonal antibody which specifically binds to chicken PAF-AH comprising the PAF-AH amino acid sequence set out in SEQ ID NO:34.
A monoclonal antibody which specifically binds to rodent PAF-AH comprising the PAF-AH amino acid sequence set out in SEQ ID NO:35.
A monoclonal antibody which specifically binds to macaque PAF-AH comprising the PAF-AH amino acid sequence set out in SEQ ID NO:36.
Dependencies are inferred from the claim text.