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US 5,847,047 AGranted
Antimicrobial composition of a polymer and a peptide forming amphiphilic helices of the magainin-type
AssigneeE. I. Du Pont de Nemours and Company
InventorSharon Loretta Haynie
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Abstract
Novel polymer-bound oligopeptides exhibiting antimicrobial activity have been develop. The oligopeptides are unique amino acid sequences that form amphiphilic helices.
Claims6
A polymer-oligopeptide consisting of:
- (i) a polymer covalently linked to
- (ii) an antimicrobial oligopeptide capable of attaining an amphiphilic helical secondary structure and selected from the group consisting of
- Lys Gly Leu Lys Lys Leu Leu Lys Leu Leu Lys Lys Leu Leu Lys Leu;
- (SEQ ID NO:
- 1),
- Leu Lys Leu Leu Lys Lys Leu Leu Lys Leu Leu Lys Lys Leu Gly Lys:
- (SEQ ID NO:2),
- Lys Gly Gly Leu Lys Lys Leu Leu Lys Leu Leu Lys Lys Leu Leu Lys Leu;
- (SEQ ID NO:3),
- Leu Lys Leu Leu Lys Lys Leu Leu Lys Leu Leu Lys Lys Leu Gly Gly Lys;
- (SEQ ID NO:4),
- Lys Gly Gly Gly Leu Lys Lys Leu Leu Lys Leu Leu Lys Lys Leu Leu Lys Leu;
- (SEQ ID NO:5), and
- Leu Lys Leu Leu Lys Lys Leu Leu Lys Leu Leu Lys Lys Leu Gly Gly Gly Lys;
- (SEQ ID NO:6).
12 more elements
Dependencies are inferred from the claim text.