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AssigneeHyal Pharmaceutical Corporation
InventorsDerek A. Willoughby, Chandan Alam, Samuel Simon Asculai, Rudolf Edgar Falk, David William Harper
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The use of: (a) a non-steroidal anti-inflammatory agent, and (b) hyaluronic acid and/or salts thereof and/or homologues, analogues, derivatives, complexes, esters, fragments, and subunits of hyaluronic acid, in the manufacture of a pharmaceutical composition for inhibiting, controlling and/or regressing angiogenesis in a therapy wherein dosage amounts taken from the composition each comprise: (1) a therapeutically effective amount of component (a); and (2) a therapeutically effective amount of the hyaluronic acid and/or salts thereof and/or homologues, analogues, derivatives, complexes, esters, fragments, and sub-units of hyaluronic acid, the pharmaceutical composition being characterized in that for each dosage amount taken from the pharmaceutical composition, the amount of components (a) and (b) inhibit, control and/or regress angiogenesis.
A container containing a composition for administration to a human for the inhibition, control and regression of angiogenesis in humans, the composition comprising a synergistic effective amounts of (a) at least one dosage amount, each such dosage amount comprising a form of diclofenac selected from the group consisting of diclofenac and diclofenac sodium and (b) a form of hyaluronic acid selected from the group consisting of hyaluronic acid and sodium hyaluronate, each dosage amount comprising an effective non-toxic dosage amount of each of the form of diclofenac and a form of hyaluronic acid to inhibit, control and regress angiogenesis in a human and wherein the effective amount of the form of hyaluronic acid is about 50 mg for each of about 15 mg of the form of diclofenac in each dosage amount to be administered and, wherein the form of hyaluronic acid has a molecular weight less than about 750,000 daltons and greater than 150,000 daltons.
A dosage amount of a pharmaceutical composition to inhibit, control or regress angiogenesis in humans, in the treatment of a disease or condition which would benefit from inhibiting, controlling or regressing angiogenesis, the dosage amount of the pharmaceutical composition comprising a synergistic effective amounts of:
Dependencies are inferred from the claim text.