Colonic delivery of nicotine to treat inflammatory bowel disease
AssigneeMayo Foundation for Medical Education and Research
InventorsWilliam J. Sandborn, John Rhodes
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Abstract
A method is provided to treat inflammatory bowel disease by locally administering to the colon an effective amount of nicotine or a pharmaceutically acceptable salt thereof, preferably via formulations adapted for delayed oral release or rectal administration. Further provided is a novel formulation for the oral administration of nicotine comprising a polyacrylic polymer complexed with nicotine.
Claims15
A therapeutic method of treating inflammatory bowel disease comprising locally administering to the rectum, colon and/or terminal ileum of a patient in need of such treatment, 0.04 to 0.1 mg/kg of nicotine, or a pharmaceutically acceptable salt thereof.
A therapeutic method of treating ulcerative colitis comprising rectally administering to a patient, an enema comprising 0.04 to 0.1 mg/kg of nicotine or a pharmaceutically acceptable salt thereof.
A delayed release orally ingestible enteric coated dosage form comprising 3 mg to 6 mg of nicotine or pharmaceutically acceptable salt thereof which is released from the dosage form in the ileum and/or colon of a patient.
Dependencies are inferred from the claim text.