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US 5,846,982 AGranted
Inhibition of serotonin reuptake
AssigneeEli Lilly and Company
InventorsJames E. Audia, Daniel J. Koch, Thomas E. Mabry, Jeffrey S. Nissen, Vincent P. Rocco, Yao-Chang Xu
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Abstract
This invention provides compounds and a method for the inhibition of serotonin reuptake in mammals.
Claims6
A compound of Formula II:
- ##STR13## where A--B is --C(R.sup.5)--CH.sub.2 --;
- R.sup.1 is H, halo, formyl, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, 4,5-dihydrothiazol-2-yl, cyano, nitro, carboxamido, trifluoromethyl or hydroxy;
- R.sup.2 is H or halo;
- R.sup.3 is H, C.sub.1 -C.sub.4 alkyl, (C.sub.1 -C.sub.4 alkylene)-aryl, or --CH.sub.2 --Y--NR.sup.7 R.sup.8 ;
- R.sup.5 is H or OH;
- R.sup.6 is H or methyl;
- Y is --CH.sub.2 -- or --C(O)--;
- R.sup.7 is pyridinyl;
- and
- R.sup.8 is H or --C(O)--(C.sub.3 -C.sub.6 cycloalkyl), provided that R.sup.1 and R.sup.2 may not both be H and pharmaceutically acceptable salts and hydrates thereof.
7 more elements
Dependencies are inferred from the claim text.