Use of amino hydrogenated quinazoline compounds and derivatives thereof for abstaining from drug dependence

A method of treating drug dependence in a human which comprises administering to the human suffering from drug dependence at least one amino hydrogenated quinazoline having the general formula I in an amount effective to cause said drug dependent human to abstain from drug-dependence ##STR7## wherein R.sub.2 and R.sub.5 each is selected from the group consisting of H, OH, and OAc;

• R.sub.1 is selected from the group consisting of H, C.sub.1 -C.sub.4 alkyl, OH, OR, OC(O)R', NH.sub.2 NHR", and NR"R"' wherein R is C.sub.1 -C.sub.6 alkyl, R' is C.sub.1 -C.sub.3 alkyl, and R", and R"' is C.sub.1 -C.sub.4 alkyl;
• R.sub.3 and R.sub.4 are .dbd.O;
• or
• when R.sub.3 is H, R.sub.4 is selected from the group consisting of:
• --ROH, wherein R is a branched or straight chain C.sub.1 -C.sub.7 alkyl,
• --CH(OH)NHOMe,
• --NAP--gly,
• --NAP--en,
• --CH.sub.2 NH.sub.2,
• --CH.sub.2 NHCH.sub.3,
• --AAG,
• --NMAG, and
• --ANT;
• or when R.sub.3 is OH or OC(O)R wherein R is C.sub.1 -C.sub.3 alkyl, R.sub.4 is selected from the group consisting of
• --CHO,
• --CH.sub.2 --gly,
• --CH.sub.2 --.beta.--Ala,
• --CH.sub.2 --Lys,
• --CH.sub.2 --en,
• --CH.sub.2 --NAP--Lys,
• --CH.sub.2 --NAP--en,
• --CH(OH)CH(NH.sub.2)COOH,
• --NH(CH.sub.2).sub.n COOH,
• --NH(CH.sub.2).sub.n NH.sub.2 and
• NH(CH.sub.2).sub.n CH(NH.sub.2)COOH
• wherein:
• n=1-6,
• en is ethylene,
• NAP is 4-triazo-2-nitrobenzoic amide,
• AAG is 2-triazo-O-aminobenzoic amide,
• NMAG is O-methylaminobenzoic amide,
• ANT is O-aminobenzoic amide.