Oral antifungal composition
AssigneeSchering Corporation
InventorsSurendra A. Sangekar, Winston A. Vadino, Ping I. Lee
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Abstract
A pharmaceutical composition comprising: i) substantially inert beads; wherein said beads are coated with ii) an antifungal agent which is (-)-(2R-cis)-4-4-4-4--5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-tr iazol-1-ylmethyl)furan-3-yl!methoxy!phenyl!-1-piperazinyl!phenyl!-2,4-dihyd ro-2-(S)-1-ethyl-2(S)-hydroxypropyl!-3H-1,2,4-triazol-3-one; iii) a binder to enables the antifungal compound to adhere to said beads. The composition enables the antifungal compound, which has very low water solubility, to have enhanced bioavailability in mammals, such as humans.
Claims19
A pharmaceutical composition comprising:
- i) a plurality of beads;
- wherein said beads are coated with
- ii) an antifungal agent of the formula:
- ##STR5## iii) a binder to enables the antifungal compound to adhere to said beads.
Dependencies are inferred from the claim text.