3-aza and 3-oxa piperidone tachykinin antagonists

A compound having the formula:

• ##STR20## or a pharmaceutically acceptable salt thereof, wherein:
• X is O, NH or NR.sup.1 ;
• R.sup.1 is C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.7 cycloalkyl C.sub.3 -C.sub.7 cycloalkyl(C.sub.1 -C.sub.4)alkyl, aryl,or aryl(C.sub.1 -C.sub.4)alkyl;
• wherein the C.sub.1 -C.sub.6 alkyl group is optionally substituted by fluoro and the C.sub.3 -C.sub.7 cycloalkyl or C.sub.3 -C.sub.7 cycloalkyl(C.sub.1 -C.sub.4 )alkyl group is optionally substituted in the cycloalkyl ring by up to two substituents each independently selected from halo, C.sub.1 -C.sub.4 alkoxy or halo(C.sub.1 -C.sub.4)alkoxy;
• and aryl means phenyl optionally substituted by halo, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, halo(C.sub.1 -C.sub.4 )alkyl or halo(C.sub.1 -C.sub.4 )alkoxy,
• R.sup.2 is phenyl optionally substituted with one or two halo substituents, indolyl or thienyl;
• R.sup.3 is NH.sub.2, --NR.sup.4 SO.sub.2 (C.sub.1 -C.sub.6 alkyl), --NR.sup.4 SO.sub.2 aryl, --NR.sup.4 CO(C.sub.1 -C.sub.6 alkyl), --NR.sup.4 CO aryl or a group of the formula:
• ##STR21## wherein W is O, NR.sup.5, CH(OH), CHCO.sub.2 H, CHN(R.sup.4).sub.2, CHF, CF.sub.2, C.dbd.O or CH.sub.2 and aryl is as previously defined;
• R.sup.4 is H or C.sub.1 -C.sub.6 alkyl;
• R.sup.5 is H, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.7 cycloalkyl, C.sub.3 -C.sub.7 cycloalkyl(C.sub.1 -C.sub.6 )alkyl, C.sub.2 -C.sub.6 alkanoyl, C.sub.4 -C.sub.8 cycloalkanoyl, C.sub.3 -C.sub.7 cycloalkyl(C.sub.2 -C.sub.6 )alkanoyl, aryl CO--,
• C.sub.1 -C.sub.6 alkyl SO.sub.2 --, C.sub.3 -C.sub.7 cycloalkyl SO.sub.2 --, C.sub.3 -C.sub.7 cycloalkyl(C.sub.1 -C.sub.6 )alkyl SO.sub.2 --, aryl-SO.sub.2 - or (R.sup.6).sub.2 NSO.sub.2 --, wherein each R.sup.6 is independently H or C.sub.1 -C.sub.4 alkyl or the two groups may be joined, to form with the nitrogen atom to which they are attached, a pyrrolidinyl, piperidino, morpholino or piperazinyl group and aryl is as previously defined;
• m is 0, 1 or 2 with the proviso that m is not 0 when W is NR.sup.5, C.dbd.O, or O;
• and n is an integer of from 1 to 4.