Cyclodextrin compounds and methods of making and use thereof
AssigneeThe Trustees of the University of Pennsylvania
InventorsMadeleine M. Joullie, Paul B. Weisz
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Abstract
The present invention provides polyanionic, substituted CDs having cellular growth modulating-activity. The invention further provides CDs having anionic groups on one side of the CD molecule. Therapeutic methods for using, as well as methods of making the CD compounds of the invention, are also disclosed herein.
Claims10
A substituted polyanionic cyclodextrin compound wherein at least about ten substituents per cyclodextrin molecule are anions of a strong acid selected from the group consisting of sulfate, nitrate, sulfonate and phosphate, said compound being associated with a physiologically acceptable cation, and at least one hydrophobic substituent including a chain of at least three atoms, wherein each one of said three atoms is selected from the group consisting of carbon atoms and sulfur atoms.
Dependencies are inferred from the claim text.