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AssigneeMarine Polymer Technologies, Inc.
InventorsJohn N. Vournakis, Sergio Finkielsztein, Ernest R. Pariser, Mike Helton
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The present invention relates to a purified, easily produced poly-.beta.-1.fwdarw.4-N-acetylglucosamine (p-GlcNAc) polysaccharide species useful in drug compositions. The p-GlcNAc of the invention is a polymer of high molecular weight whose constituent monosaccharide sugars are attached in a .beta.1.fwdarw.4 conformation, and which is free of proteins, and substantially free of single amino acids, and other organic and inorganic contaminants. In addition, derivatives and reformulations of p-GlcNAc are described. The present invention further relates to methods for the purification of the p-GlcNAc of the invention from microalgae, preferably diatom, starting sources. Still further, the invention relates to methods for the derivatization and reformulation of the p-GlcNAc. Additionally, the present invention relates to the uses of pure p-GlcNAc, its derivatives, and/or its reformulations.
A drug/poly-.beta.-1.fwdarw.4-N-acetylglucosamine composition comprising poly-.beta.-1.fwdarw.4-N-acetylglucosamine comprising about 4,000 to about 150,000 N-acetylglucosamine monosaccharides covalently attached in a .beta.-1.fwdarw.4 conformation, free of protein, substantially free of other organic contaminants, substantially free of inorganic contaminants, and having a molecular weight of about 800,000 daltons to about 30 million daltons within which a drug is encapsulated.
A drug/poly-.beta.-1.fwdarw.4-glucosamine composition comprising poly-.beta.-1.fwdarw.4-glucosamine comprising about 4,000 to about 150,000 glucosamine monosaccharides covalently attached in a .beta.-1.fwdarw.4 conformation, free of protein, substantially free of other organic contaminants, substantially free of inorganic contaminants, and having a molecular weight of about 640,000 daltons to about 24 million daltons within which a drug is encapsulated.
A drug/poly-.beta.-1.fwdarw.4-N-acetylglucosamine comprising poly-.beta.-1.fwdarw.4-N-acetylglucosamine of about 4,000 to about 150,000 N-acetylglucosamine monosaccharides covalently attached in a .beta.-1.fwdarw.4 conformation, free of protein, substantially free of other organic contaminants, substantially free of inorganic contaminants, and having a molecular weight of about 800,000 daltons to about 30 million daltons wherein at least one N-acetylglucosamine monosaccharide has been deacetylated, and where at least one peptide is functionally attached to the deacetylated monosaccharide of the poly-.beta.-1.fwdarw.4-N-acetylglucosamine.
A drug/poly-.beta.-1.fwdarw.4-glucosamine composition comprising poly-.beta.-1.fwdarw.4-glucasamine of about 4,000 to about 150,000 glucosamine monosaccharides covalently attached in a .beta.-1.fwdarw.4 conformation, free of protein, substantially free of other organic contaminants, substantially free of inorganic contaminants, and having a molecular weight of about 640,000 daltons to about 24 million daltons wherein at least one glucosamine monosaccharide of the poly-.beta.-1.fwdarw.4-glucosamine contains a peptide functionally attached thereto.
Dependencies are inferred from the claim text.