Pharmaceutical composition for promoting the proliferation of human corneal endothelium and a method for using thereof

Abstract

A pharmaceutical composition for promoting the proliferation of human corl endothelium comprising: 1 ml of 0.15M phosphate buffer, at pH 7.4; 400-800 .mu.g of heparin; 1.0-5.0 .mu.g of Cu.sup.2+ ; 37.5-375 .mu.g of /3-0-b-D-gelactopyranosyl-(1-4)-0-(2-acetamido-b-D-glucopyranosyl-6-sulfat e)-1/as the salt of a basic metal; and 12.5-125 .mu.g of copolymer (b-gucuronic acid (1-3)-N-acetyl-b-galactosamino-4-(or 6-) -sulfate-(1-4) as the salt of a basic metal. Such a composition is particularly useful for promoting the proliferation of human corneal endothelium in conditions associated with cataract extraction followed by artificial lens implantation, wherein the composition is injected into the patient's anterior eye chamber in an amount of between 0.2-02.25 ml, immediately after performing the operation. In all other cases, the pharmaceutical composition is injected into a patient's anterior eye chamber by phonophoresis in a continuous mode, at intensity 0.1-0.3 V/cm.sup.2 for 10 minutes, with the composition used in the amount of 5 ml daily for 4-6 days.

Dependencies are inferred from the claim text.