Modified ciliary neurotrophic factors
AssigneeRegeneron Pharmaceuticals, Inc.
InventorNikos Panayotatos
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Abstract
Modified ciliary neurotrophic factors and methods for their production and therapeutic use. Also described is a method of screening for novel therapeutic proteins by determining altered electrophoretic binding properties.
Claims14
Modified human ciliary neurotrophic factor comprising human ciliary neurotrophic factor having the modifications Gln63.fwdarw.Arg and Trp64.fwdarw.Ala.
Modified human ciliary neurotrophic factor comprising human ciliary neurotrophic factor having the modifications Gln63.fwdarw.Arg, Cys17.fwdarw.Ala and a deletion of the C-terminal 13 amino acid residues.
Modified human ciliary neurotrophic factor comprising human ciliary neurotrophic factor having the modifications Gln63.fwdarw.Arg and a deletion of the C-terminal 13 amino acid residues.
Dependencies are inferred from the claim text.