Back to results
US 5,846,823 AGranted
Expression of human D4 dopamine receptors in stable cell lines
AssigneeAllelix Biopharmaceuticals Inc.
InventorsJoshua Owolabi, Vikarna Rampersad, Rajender Kamboj
Life of this patent
Estimating the term…
Abstract
Cell lines that stably incorporate human D.sub.4 receptor-encoding DNA are provided which are particularly useful in procedures for screening compounds for potential anti-psychotic activity.
Claims1
A cell line engineered genetically to produce a human D.sub.4 receptor, the cells of said cell line having incorporated expressibly into the cellular DNA thereof a construct comprising a nucleotide sequence encoding a human dopamine D.sub.4 receptor, wherein said nucleotide sequence is modified at its flanks to incorporate the following:
- (1) the 5' non-coding region of SEQ ID NO:9 or SEQ ID NO:12;
- and
- (2) a 3' non-coding region of SEQ ID NO:10 or SEQ ID No:11.
Dependencies are inferred from the claim text.