Nucleic acid molecules encoding a novel receptor-type protein tyrosine phosphatase-.sigma.
AssigneeNew York University
InventorsJoseph Schlessinger, Hai Yan
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Abstract
The present invention relates to a novel receptor-type protein tyrosine phosphatase protein or glycoprotein, termed RPTP.sigma. (also known as RPTPase-.sigma.), DNA coding therefor, antibodies specific for the protein or glycoprotein, methods for production and identification of the protein, methods for detection of nucleic acid encoding the protein, and methods for screening compounds capable of binding to and either inhibiting or stimulating RPTP.sigma. phosphatase activity.
Claims18
An isolated nucleic acid molecule comprising a nucleotide sequence that encodes a polypeptide having the amino acid sequence SEQ ID NO:3.
The isolated nucleic acid molecule of claim 4, wherein the nucleotide sequence comprises the RPTP.sigma.-coding nucleotide sequence depicted in SEQ ID NO:2.
An isolated nucleic acid molecule comprising a nucleotide sequence that encodes one of the following domains of RPTP.sigma. having SEQ ID NO:3:
- one of the three Ig-like domains, one of the five fibronectin type III repeats, the signal peptide, the transmembrane domain, the extracellular domain, or one of the two phosphatase domains.
Dependencies are inferred from the claim text.