Back to results
US 5,846,791 AGranted
N-(R)-(2-hydroxy-2-pyridine-3-yl-ethyl)-2-(4-nitro-phenyl)-acetamide
AssigneeMerck & Co., Inc.
InventorsMichel M. Chartrain, John Y. L. Chung, Christopher Roberge
Life of this patent
Estimating the term…
Abstract
Asymmetric bioreduction of a ketone substrate with yeast produces the corresponding (R)-alcohol of structure: ##STR1## a key intermediate in the synthesis of a .beta..sub.3 -agonist of structure ##STR2##
Claims6
A process for the preparation of a compound of structural formula I:
- ##STR8## which comprises incubating a substrate of structural formula III:
- ##STR9## with Candida Sorbophila, ATCC Accension No. 74362 in a nutrient medium.
Dependencies are inferred from the claim text.