Murine RATH gene
AssigneeMillennium Pharmaceuticals, Inc.
InventorsDouglas Adam Levinson, Carlos J. Gimeno
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Abstract
The present invention relates, first, to the identification of novel nucleic acid molecules and proteins encoded by such nucleic acid molecules, or degenerate variants thereof, that participate in the regulation, control and/or modulation of G-protein-mediated signal transduction involved in T cell activation, including, but not limited to T helper (TH) cell and TH cell subpopulation activation. Specifically, the nucleic acid molecules of the present invention include the genes corresponding to the mammalian R11 gene, including the human R11 gene. R11 sequence analysis indicates that the R11 gene is a novel gene belonging to the RGS ("regulator of G-protein signalling") gene family, a gene family which encodes gene products involved in G-protein-mediated signal transduction.
Claims19
An isolated nucleic acid molecule comprising:
- (a) a nucleotide sequence that encodes a polypeptide having the amino acid sequence of FIGS. 1A-1C (SEQ ID NO:2);
- (b) the complement of the nucleotide sequence of (a);
- or
- (c) a RATH gene or a complement of a RATH gene as contained in ATCC Deposit No. 98116.
An isolated nucleic acid molecule comprising the nucleotide sequence of FIGS. 1A-1C (SEQ ID NO:1).
An isolated nucleic acid molecule which encodes a polypeptide comprising the amino acid sequence of SEQ ID NO:2 missing amino acid residues 60 to 179 of FIGS. 1A-1C (SEQ ID NO:2).
A nucleic acid molecule comprising:
- (a) a nucleotide sequence encoding a polypeptide comprising amino acid residues 60 to 179 of FIGS. 1A-1C (SEQ ID NO:2);
- or (b) the complement of the nucleotide sequence of (a).
Dependencies are inferred from the claim text.