Single gene encoding aortic-specific and striated-specific muscle cell isoforms and uses thereof
AssigneePresident and Fellows of Harvard College
InventorsMu-En Lee, Chung-Ming Hsieh
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Abstract
Aortic-preferentially-expressed gene-1 (APEG-1) and striated muscle preferentially expressed (SPEG) polypeptide, DNA sequences encoding and controlling the transcription of the APEG-1/SPEG encoding gene, methods of diagnosing vascular injury, methods of conferring smooth muscle-cell specific expression, and methods of inhibiting vascular smooth muscle cell proliferation by increasing the level of APEG-1 at the site of vascular injury.
Claims8
A substantially pure DNA comprising an APEG-1 promoter/enhancer sequence, wherein said promoter/enhancer sequence is operably linked to a polypeptide-encoding sequence and regulates vascular smooth muscle cell-specific transcription of said polypeptide-encoding sequence.
Dependencies are inferred from the claim text.