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AssigneeSmithKline Beecham Corporation
InventorsJohn Edward Hodgson, Nicola Gail Wallis
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Novel response regulator polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polynucleotides and polypeptides for the treatment of infection, particularly bacterial infections. Antagonists against such the polypeptides of the invention and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence the nucleic acid sequences and the polypeptides of the invention in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding response regulators and for detecting the polypeptide in a host.
An isolated polynucleotide encoding a two component signal transduction system response regulator protein derived from Staphylococcus aureus, said polynucleotide comprising a member selected from the group consisting of:
An isolated polynucleotide encoding a two component signal transduction system response regulator protein derived from Staphylococcus aureus, said polynucleotide comprising a member selected from the group consisting of:
An isolated polynucleotide encoding a two component signal transduction system response regulator protein derived from Staphylococcus aureus, said polynucleotide comprising a polynucleotide sequence having at least a 95% identity to a polynucleotide sequence encoding a polypeptide consisting of the amino acids of SEQ ID NO:2.
An isolated polynucleotide encoding a two component signal transduction system response regulator protein derived from Staphylococcus aureus, said polynucleotide comprising a polynucleotide sequence having at least a 95% identity to a polynucleotide sequence encoding the same mature polypeptide expressed by the gene comprising the polynucleotide sequence of SEQ ID NO:1 and contained in NCIMB Deposit No. 40771.
An isolated polynucleotide encoding a two component signal transduction system response regulator protein derived from Staphylococcus aureus, said polynucleotide comprising a polynucleotide sequence having at least a 97% identity to a polynucleotide sequence encoding a polypeptide consisting the amino acid sequence of SEQ ID NO:2.
An isolated polynucleotide encoding a two component signal transduction system response regulator protein derived from Staphylococcus aureus, said polynucleotide comprising a polynucleotide sequence having at least a 97% identity to a polynucleotide sequence encoding the same mature polypeptide expressed by gene comprising the polynucleotide of SEQ ID NO:
An isolated polynucleotide comprising a polynucleotide sequence encoding a polypeptide comprising amino acids of SEQ ID NO:2.
An isolated RNA encoding a two component signal transduction system response regulator protein derived from Staphylococcus aureus, said RNA comprising an RNA sequence having at least a 70% identity to a polynucleotide encoding a polypeptide consisting of the amino acid sequence of SEQ ID NO:2.
An isolated RNA encoding a two component signal transduction system response regulator protein derived from Staphylococcus aureus, said RNA comprising an RNA sequence having at least a 95% identity to a polynucleotide encoding a polypeptide consisting of the amino acid sequence of SEQ ID NO:2.
An isolated RNA encoding a two component signal transduction system response regulator protein derived from Staphylococcus aureus, said RNA comprising a RNA sequence having at least a 97% identity to a polynucleotide encoding a polypeptide consisting of the amino acid sequence of SEQ ID NO:2.
An isolated RNA comprising an RNA sequence encoding the polypeptide sequence of SEQ ID NO:2.
An isolated RNA consisting of an RNA sequence transcribed from nucleotides 175 through 804 of SEQ ID NO:1.
A pharmaceutical composition comprising DNA encoding a protein having the amino acid sequence of SEQ ID NO:2.
A pharmaceutical composition comprising DNA comprising SEQ ID NO:1.
A pharmaceutical composition comprising RNA encoding a protein having the amino acid sequence of SEQ ID NO:2.
A pharmaceutical composition comprising DNA encoding a polypeptide comprising amino acids 1-20, 21-40, 41-60, 61-80, or 81-100 of SEQ ID NO:2.
A pharmaceutical composition comprising RNA encoding a polypeptide comprising amino acids 1-20, 21-40, 41-60, 61-80, or 81-100 of SEQ ID NO:2.
Dependencies are inferred from the claim text.