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US 5,846,739 AGranted
Immunohistochemical detection assay for carcinoma proliferative status
AssigneeWisconsin Alumni Research Foundation
InventorsMichael N. Gould, Steven P. Stoesz
Life of this patent
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Abstract
A method of determining the proliferative status of a carcinoma is disclosed. One obtains a patient sample and then quantitatively analyzes the sample for NGAL gene expression product. The amount of NGAL expression product is compared with a standard curve to determine the S-phase value. The sample can be breast tissue or breast fluid aspirate. Alternatively, blood can by analyzed for this marker to diagnose metastasis.
Claims4
A method of determining the relative degree of proliferation of a human breast carcinoma, comprising:
- (a) obtaining a sample of the carcinoma;
- (b) using an antibody having specificity for NGAL protein to bind to NGAL protein in the sample;
- (c) using a marker bound to the antibody to indicate the extent to which NGAL protein is present in the carcinoma.
Dependencies are inferred from the claim text.