CD46 variants
AssigneeThe Austin Research Institute
InventorsDamian Francis John Purcell, Sarah May Russell, Ian Farquar Campbell McKenzie
Life of this patent
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Abstract
CD46 (membrane cofactor protein) is a family of human cell surface glycoprotein with cofactor activity for factor I mediated cleavage of complement components C3b and C4b. Disclosed are novel nucleic acid sequences arising from splice variants or derivatives thereof of the structural gene encoding the family of proteins. From these sequences recombinant derived proteins and antibodies thereto can be produced. The proteins can resemble native CD46 isoforms or comprise new permutations of exons within the structural gene. The nucleic acids, proteins and antibodies have utility as probes, diagnostic reagents and therapeutic agents.
Claims13
An isolated polynucleotide encoding CD46 isoform PM5.3 (SEQ ID NO:42).
An isolated polynucleotide encoding CD46 isoform PM5.3 (SEQ ID NO:44).
An isolated polynucleotide encoding CD46 isoform PM5.8 (SEQ ID NO:46).
An isolated polynucleotide that encodes a CD46 isoform that comprises amino acids 1-336 of SEQ ID NO:42.
An isolated polynucleotide that encodes a CD46 isoform that comprises amino acids 1-339 of SEQ ID NO:44.
An isolated polynucleotide that encodes a CD46 isoform that comprises amino acids 1-290 of SEQ ID NO:46.
Dependencies are inferred from the claim text.