Herpes simplex virus as a vector
AssigneeArch Development Corporation
InventorBernard Roizman
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Abstract
A foreign gene is inserted into a viral genome under the control of promoter-regulatory regions of the genome, thus providing a vector for the expression of the foreign gene. DNA constructs, plasmid vectors containing the constructs useful for expression of the foreign gene, recombinant viruses produced with the vector, and associated methods are disclosed.
Claims23
A recombinant viral genome of a herpes simplex virus containing an expressible non-viral gene permanently integrated at a site of said genome.
A plasmid vector containing an expressible non-viral gene permanently integrated at a site of a genome of a herpes simplex virus.
A method of preparing a recombinant viral genome of a herpes simplex virus, said method comprising the steps of:
- (a) isolating a genome of said herpes simplex virus;
- and
- (b) permanently integrating into said genome at a site thereof an expressible non-viral gene.
A recombinant viral genome of a herpes simplex virus containing an expressible non-HSV nucleotide sequence permanently integrated at a site of said genome.
A plasmid vector containing an expressible non-HSV nucleotide sequence permanently integrated at a site of a genome of a herpes simplex virus.
A method of preparing a recombinant viral genome of a herpes simplex virus, said method comprising the steps of:
- (a) isolating a genome of said herpes simplex virus;
- and, (b) permanently integrating into said genome at a site thereof an expressible non-HSV nucleotide sequence.
Dependencies are inferred from the claim text.