Restoration of normal phenotype in cancer cells
AssigneeThe Regents of the University of California
InventorsMina J. Bissell, Valerie M. Weaver
Life of this patent
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Abstract
A method for reversing expression of malignant phenotype in cancer cells is described. The method comprises applying .beta..sub.1 integrin function-blocking antibody to the cells. The method can be used to assess the progress of cancer therapy. Human breast epithelial cells were shown to be particularly responsive.
Claims8
A method to reverse expression of malignant phenotypes chosen from the group consisting of growth control, apoptosis control, cell colony organization, actin organization, formation of adherens junctions, and responsiveness to presence of basement membrane in cultured mammalian breast cells comprising, applying .beta..sub.1 integrin specific antibody or a .beta..sub.1 integrin specific binding fragment thereof or a .beta..sub.1 integrin specific binding peptide therefrom to the cells.
Dependencies are inferred from the claim text.