Antibodies to the antigen campath-1
AssigneeBritish Technology Group Limited
InventorsHerman Waldmann, Michael R. Clark, Gregory P. Winter, Lutz Riechmann
Life of this patent
Estimating the term…
Abstract
An antibody is produced, which will bind effectively with the antigen Campath-1, and which has at least one complementarity determining region of rat origin, as identified in FIG. 2, which may be combined with a range of different foreign variable domain framework regions as desired, including framework regions of human origin.
Claims18
An antibody which binds effectively to the antigen Campath-1, having a constant region of human origin, heavy and light chain variable domain framework regions which are of human origin, and complementarity determining regions defined by amino acid residues 31 to 35, 50 to 65 and 95 to 102 of the heavy chain as shown in FIG. 2a, and amino acid residues 24 to 34, 50 to 56 and 89 to 97 of the light chain as shown in FIG. 2b, the heavy chain variable domain framework region having a phenylalanine residue at 27.
A method of treating a human patient having a lymphoid malignancy, which comprises administering an antibody which binds effectively to the antigen Campath-1, having a constant region of human origin, heavy and light chain variable domain framework regions which are of human origin, and complementarity determining regions defined by amino acid residues 31 to 35, 50 to 65 and 95 to 102 of the heavy chain as shown in FIG. 2a, and amino acid residues 24 to 34, 50 to 56 and 89 to 97 of the light chain as shown in FIG. 2b, the heavy chain variable domain framework region having a phenylalanine residue at 27.
Dependencies are inferred from the claim text.