Continuous cell line and vaccine against avian coccidia
AssigneePfizer Inc.
InventorsTimothy J. Miller, Robert A. Clare, Patricia Lufburrow
Life of this patent
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Abstract
A non-lymphoid continuous cell line adapted for propagation of avian coccidia is provided. This cell line is useful for the production of vaccine antigenes for prophylactic treatment of poultry, particularly in a novel vaccine for coccidia.
Claims10
A vaccine against coccidiosis, comprising a cell culture component collected from a culture of cells of cell line SB-CEV-1.backslash.P (ATCC CRL 10497) or a cell line derived therefrom which is able to replicate the prepatent life cycle of an Eimeria avian parasite, which cells are infected with a selected Eimeria avian parasite, wherein the cell culture component is selected from the group consisting of a whole cell culture preparation, conditioned media which provides significant weight gain protection or significant improved feed conversion, intact infected host cells, disrupted infected host cells, or a combination thereof, and further comprising an oil in water adjuvant.
A method for vaccinating poultry against infection by parasites causing coccidiosis, comprising administering to poultry an effective dose of a vaccine comprising a cell culture component collected from a culture of cells of cell line SB-CEV-1.backslash.P (ATCC CRL 10497) or a cell line derived therefrom which is able of replicate the prepatent life cycle of an Eimeria avian parasite, which cells are infected with a selected Eimeria avian parasite, wherein the cell culture component is selected from the group consisting of a whole cell culture preparation, conditioned media which provides significant weight gain protection or significant improved feed conversion, intact infected host cells, disrupted infected host cells, or a combination thereof, and further comprising an oil in water adjuvant.
Dependencies are inferred from the claim text.