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US 5,846,521 AGranted
Pressurized solvent-free drug aerosol compositions containing hydrofluorocarbon propellants
AssigneeFisons Limited
InventorsAsit Somani, Clive Booles
Life of this patent
Estimating the term…
Abstract
Pressurised aerosol compositions comprise a medicament, a hydrofluorocarbon propellant and a polyethoxylated surfactant, the compositions containing substantially no solvent, other than the propellant, capable of increasing the solubility of the surfactant in the propellant. The compositions according to the invention are advantageous in that the solubility of the surfactant is such as to ensure good dispersion of the medicament and smooth operation of the aerosol valve.
Claims14
A pressurized aerosol composition consisting essentially of
- a medicament in an amount up to 15% by weight of the composition;
- a hydrofluorocarbon propellant;
- and
- a surfactant having a molecular weight less than 20,000 which is selected from the group consisting of polyethylene glycol, a block copolymer of ethylene oxide and propylene oxide, and a polyethoxylated surfactant having a hydrophobic portion derived from an alkyl phenol, a monohydric alcohol, a polyhydric alcohol which can be partially esterified, or ethylene diamine;
- said composition containing about 0.01% to 10% by weight of said surfactant;
- the vapor pressure of said composition being in the range of 20-100 psi;
- and
- the composition being free from any solvent, other than the propellant, which increases the solubility of the surfactant in the propellant.
5 more elements
A pressurized aerosol composition consisting essentially of
- a medicament in an amount up to 15% by weight of the composition;
- a hydrofluorocarbon propellant selected from the group consisting of (1,1,1,2)-tetrafluoroethane, (1,1,1,2,3,3,3)-heptafluoropropane, and mixtures thereof;
- and
- a surfactant having a molecular weight less than 20,000 which is selected from the group consisting of polyethylene glycol, a block copolymer of ethylene oxide and propylene oxide, and a polyethoxylated surfactant having a hydrophobic portion derived from an alkyl phenol, a monohydric alcohol, a polyhydric alcohol which can be partially esterified, or ethylene diamine;
- said composition containing about 0.01% to 10% by weight of said surfactant;
- the vapor pressure of said composition being in the range of 20-100 psi;
- and
- the composition being free from any solvent, other than the propellant, which increases the solubility of the surfactant in the propellant.
5 more elements
Dependencies are inferred from the claim text.