Gene transfer therapy delivery device and method

A device for delivering a fluid into tissue at multiple locations generally simultaneously, the device comprising:

• a syringe-receiving portion adapted for receiving a plurality of pre-loaded syringes in an adjacently configured, substantially parallel manner, each syringe having a lumen for containing the fluid to be expelled into the tissue, a needle for penetrating the tissue, and a syringe plunger movable within said lumen for expelling the fluid through said needle;
• a plunger portion connectable to the syringe-receiving portion and having a movable main plunger for moving said syringe plungers generally simultaneously for delivering the fluid to the tissue;
• and
• a platen movably mounted on said syringe-receiving portion for contacting the tissue prior to penetration by said needles, said platen being spring-biased to provide a resistance prior to penetration of the tissue by said needles.

A device for delivering a fluid into tissue at multiple locations generally simultaneously, the device comprising:

• a syringe-receiving portion adapted for receiving a plurality of pre-loaded syringes in an adjacently configured, substantially parallel manner, each syringe having a lumen for containing the fluid to be expelled into the tissue, a needle for penetrating the tissue, and a syringe plunger movable within said lumen for expelling the fluid through said needle;
• a plunger portion connectable to the syringe-receiving portion and having a movable main plunger for moving said syringe plungers generally simultaneously for delivering the fluid to the tissue;
• and
• a platen movably mounted on said syringe-receiving portion for contacting the tissue prior to penetration by said needles, said platen being spring-biased to provide a resistance prior to penetration of the tissue by said needles, and wherein said platen covers the tips of said needles prior to contacting said platen to the tissue.

A method of delivering multiple doses of a fluid into biological tissue generally simultaneously, the method comprising:

• providing a device containing a plurality of syringes, each said syringe having a lumen for containing the fluid and a needle for dispensing the fluid, said lumens of said syringes being in fluid isolation from each other, said device including a means for generally simultaneously expelling the contents of said syringes, said device further including a platen having a surface for pressing against the tissue;
• pressing said surface against the tissue so that the tissue assumes the shape of said surface;
• penetrating the tissue with said needles;
• expelling the contents of said syringes generally simultaneously;
• and
• wherein said platen is movably connected to the device containing the plurality of syringes and is spring biased so that the tissue assumes the shape of said surface due to spring resistance.