Glycohydrolase inhibitors, their preparation and use thereof
AssigneeUniversity of Maryland, Baltimore County
InventorsMichael R. Sierks, Mikael Bols, Troels Skrydstrup
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Abstract
A compound of the formula ##STR1## wherein n, m, and p, which may be the same or different, are a number between 0 and 5; q is a number between 0 and 10; R.sub.1, R.sub.2 R.sub.3 R.sub.4 and R.sub.5, which may be the same or different, are a hydrogen, a hydroxyl, a halogen, a hydrocarbon or an O-hydrocarbon group having between 1 and 6 carbons which is aliphatic, alicyclic or aromatic, or a glycosyl group; and R.sub.4 is a glycosyl group, is disclosed. Nitrogen oxides of such compounds are also included. These novel compounds have been found to be potent glycohydrolase inhibitors. Processes for preparing these novel compounds and methods for their use in the treatment of diabetes mellitus are also provided.
Claims10
A compound of the formula ##STR9## wherein n, m, and p, which may be the same or different, are a number between 0 and 5;
- q is a number between 0 and 10;
- R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5, which may be the same or different, are a hydrogen, a hydroxyl, a halogen atom, a hydrocarbon or an O-hydrocarbon group having between 1 and 6 carbons which is aliphatic, alicyclic or aromatic, or a glycosyl group;
- and R.sub.6 is a glycosyl group.
A compound of the formula ##STR12## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.7, R.sub.8, R.sub.9 and R.sub.10, which may be the same or different, are a hydrogen, a hydroxyl, a halogen, a hydrocarbon or an O-hydrocarbon group having between 1 and 6 carbons which is aliphatic, alicyclic or aromatic, or a glycosyl group.
Dependencies are inferred from the claim text.