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US 5,844,099 AGranted
Cytokine antagonists
AssigneeRegeneron Pharmaceuticals, Inc.
InventorsNeil Stahl, Aris Economides, George D. Yancopoulos
Life of this patent
Estimating the term…
Abstract
Heteromeric proteins comprising a soluble .alpha. specificity determining cytokine receptor component and the extracellular domain of a .beta. receptor component function as cytokine antagonists.
Claims17
A purified antagonist of a cytokine comprising:
- a) the extracellular domain but not the transmembrane and cytoplasmic domains of the specificity determining component of the cytokine's receptor;
- and
- b) the extracellular domain but not the transmembrane and cytoplasmic domains of a signal transducing component of the cytokine's receptor;
- wherein the cytokine is selected from the group consisting of interleukin-1, interleukin-2, interleukin-3, interleukin-4, interleukin-5, interleukin-15, granulocyte macrophage colony stimulating factor, gamma-interferon, and Transforming Growth Factor-Beta, and the antagonist is capable of binding the cytokine to form a nonfunctional complex.
1 more element
A purified antagonist of interleukin-1 comprising:
- a) the extracellular domain but not the transmembrane and cytoplasmic domains of the specificity determining component of the interleukin-1 receptor;
- and
- b) the extracellular domain but not the transmembrane and cytoplasmic domains of the signal transducing component of the interleukin-1 receptor;
- wherein the antagonist is capable of binding interleukin-1 to form a nonfunctional complex.
1 more element
A purified antagonist of interleukin-2 comprising:
- a) the extracellular domain but not the transmembrane and cytoplasmic domains of the specificity determining component of the interleukin-2 receptor;
- and
- b) the extracellular domain but not the transmembrane and cytoplasmic domains of the signal transducing component of the interleukin-2 receptor;
- wherein the antagonist is capable of binding interleukin-2 to form a nonfunctional complex.
1 more element
A purified antagonist of interleukin-3 comprising:
- a) the extracellular domain but not the transmembrane and cytoplasmic domains of the specificity determining component of the interleukin-3 receptor;
- and
- b) the extracellular domain but not the transmembrane and cytoplasmic domains of the signal transducing component of the interleukin-3 receptor;
- wherein the antagonist is capable of binding interleukin-3 to form a nonfunctional complex.
1 more element
A purified antagonist of interleukin-4 comprising:
- a) the extracellular domain but not the transmembrane and cytoplasmic domains of the specificity determining component of the interleukin-4 receptor;
- and
- b) the extracellular domain but not the transmembrane and cytoplasmic domains of the signal transducing component of the interleukin-4 receptor;
- wherein the antagonist is capable of binding interleukin-4 to form a nonfunctional complex.
1 more element
A purified antagonist of interleukin-5 comprising:
- a) the extracellular domain but not the transmembrane and cytoplasmic domains of the specificity determining component of the interleukin-5 receptor;
- and
- b) the extracellular domain but not the transmembrane and cytoplasmic domains of the signal transducing component of the interleukin-5 receptor;
- wherein the antagonist is capable of binding interleukin-5 to form a nonfunctional complex.
1 more element
A purified antagonist of interleukin-15 comprising:
- a) the extracellular domain but not the transmembrane and cytoplasmic domains of the specificity determining component of the interleukin-15 receptor;
- and
- b) the extracellular domain but not the transmembrane and cytoplasmic domains of the signal transducing component of the interleukin-15 receptor;
- wherein the antagonist is capable of binding interleukin-15 to form a nonfunctional complex.
1 more element
A purified antagonist of granulocyte macrophage colony stimulating factor comprising:
- a) the extracellular domain but not the transmembrane and cytoplasmic domains of the specificity determining component of the granulocyte macrophage colony stimulating factor receptor;
- and
- b) the extracellular domain but not the transmembrane and cytoplasmic domains of the signal transducing component of the granulocyte macrophage colony stimulating factor receptor;
- wherein the antagonist is capable of binding granulocyte macrophage colony stimulating factor to form a nonfunctional complex.
1 more element
A purified antagonist of gamma-interferon comprising:
- a) the extracellular domain but not the transmembrane and cytoplasmic domains of the specificity determining component of the gamma-interferon receptor;
- and
- b) the extracellular domain but not the transmembrane and cytoplasmic domains of the signal transducing component of the gamma-interferon receptor;
- wherein the antagonist is capable of binding gamma-interferon to form a nonfunctional complex.
1 more element
A purified antagonist of Transforming Growth Factor-Beta comprising:
- a) the extracellular domain but not the transmembrane and cytoplasmic domains of the specificity determining component of the Transforming Growth Factor-Beta receptor;
- and
- b) the extracellular domain but not the transmembrane and cytoplasmic domains of the signal transducing component of the Transforming Growth Factor-Beta receptor;
- wherein the antagonist is capable of binding Transforming Growth Factor-Beta to form a nonfunctional complex.
1 more element
Dependencies are inferred from the claim text.