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AssigneeBoard of Regents of the University of Nebraska
InventorsSteven H. Hinrichs, Dana Jo Orten
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The present invention relates to members of the cyclic AMP responsive element binding protein/activating transcription factor 1 (CREB/ATF1) family of transcription factors. An embodiment of this invention constitutes an inhibitory agent (e.g., an antibody, small molecule or polypeptide) which binds to a fragment, spanning from about position 167 to about 181 of the amino acid sequence of the ATF1 protein bound to the target gene, with sufficient binding affinity to cause disassociation of ATF1 from the DNA of the target gene and/or prevent ATF1 from binding thereto through a currently unknown mechanism. As a result, transcription is prevented or, at least, inhibited, resulting in events of consequence to a virus or cell.
An inhibitory compound which binds to a fragment spanning from about position 167 to about position 181 of the amino acid sequence of the ATF1 protein with sufficient binding affinity to cause disassociation of ATF1 from the DNA of the gene to which ATF1 is bound and prevent transcription.
An antibody, or antibody fragment, specific for SEQ ID NO:1.
Dependencies are inferred from the claim text.